Researchers used a novel phosphate-activation reagent, 2-MeImIm-Cl, in an improved coupling reaction to increase the yield of ADP- or ATP-containing molecules. Unlike traditional reactions, the ...
The primary functions of the proteasome are driven by a highly allosteric ATPase complex. ATP binding to only two subunits in this hexameric complex triggers substrate binding, ATPase–20S association ...
Purines are heterocyclic aromatic molecules that are among the oldest and most influential biochemical compounds in evolutionary history. 1 The purine nucleotide adenosine triphosphate (ATP) is the ...
Hsp90 plays a central role in cell homeostasis by assisting folding and maturation of a large variety of clients. It is a homo-dimer, which functions via hydrolysis of ATP-coupled to conformational ...
Reversible modification of mitochondrial ADP/ATP translocases by paired Legionella effector proteins
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 23 (June 7, 2022), pp. 1-11 (11 pages) Adenosine diphosphate (ADP) ribosylation is a reversible ...
A so-called "molecular chaperone", the protein Hsp70, carries out more functions in the maturation of proteins than previously thought. As the researchers have discovered, Hsp70 not only acts as a ...
A new study led by Rice University's Pernilla Wittung-Stafshede has revealed that protein clumps, or plaques that clog the brain, associated with Parkinson's disease are not merely waste; they can ...
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