New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

Previously unknown access points in cell membrane proteins have been discovered, enabling laboratory-developed drugs to modify cell function. The discovery was made possible through computer ...

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are ...

G-protein-coupled receptors (GPCRs) remain major drug targets, despite an incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named the ...

While investigating why cholesterol-lowering drugs called statins cause negative side effects such as blurred vision, short-term memory loss or increased risk for diabetes, cellular chemists at The ...

This new article publication from Acta Pharmaceutica Sinica B, discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a ...