G protein–coupled receptors (GPCRs) play crucial roles in the regulation of a wide variety of physiological processes and represent one-third of targets with clinically prescribed drugs. Yet, it ...

Signal transduction is a key mechanism that brings about several physiological responses in a cell. Aberrant signaling can result due to gene mutations or regulatory protein overexpression. It is ...

Using advanced imaging methods, researchers have gained insight into how a common target of drugs sends cellular signals, a finding that may lead to better and more precise therapeutics. Roughly a ...

SEATTLE--(BUSINESS WIRE)--Omeros Corporation (Nasdaq: OMER) today announced a new approach to cancer immunotherapy that targets inhibition of GPR174, a member of the family of G protein-coupled ...